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Rationale for 60 day window to define subsequent diseaseAs stated previously, women were referred for colposcopy and cervical surgery in accordance with a triage algorithm.1 2 In FUTURE I, the pre specified primary end points included all HPV related anogenital disease, thus the study included stringent criteria for disease determination and follow up, including more frequent examinations and screening and more aggressive colposcopy triage for suspected disease. In FUTURE II, the primary end point was cervical intraepithelial neoplasia grade II III and adenocarcinoma in situ. Treatment of vulvar or vaginal disease in FUTURE II was based on local standards of care, and the investigators were not required to record the date or method of treatment.

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